{"success":true,"data":{"pressRelease":{"id":"94865","rtpr_id":"nPn7KxgzGa","ticker":"ELAN","exchange":"NYSE","all_tickers":["ELAN"],"title":"Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)","author":"PR Newswire","published_at":"2026-07-22T10:27:00.017Z","article_body":"Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)\n\nPR Newswire\n\nINDIANAPOLIS, July 22, 2026\n\nPublished Data Shows that the Active Ingredient, Lotilaner, in Credelio\nQuattro:\n\n * Kills existing black-legged tick (Ixodes scapularis) infestations faster(2)\nthan leading competitors, within just 8 hours of treatment.(i)\n * Kills the lone star tick (Amblyomma americanum) within 12 hours of\ninfestation; achieving the fastest(3) initial speed of tick kill compared to\nthe competition.(ii)\n * Achieves a rapid speed of kill(4) on Day 0 and on Day 28, with no\nstatistically significant drop-off in performance at the end of the dosing\nperiod.(i,ii)\n * Outlasts competitors whose speed of kill(2,4) performance declined at the end\nof the month.(i,ii)\nINDIANAPOLIS, July 22, 2026 /PRNewswire/ -- When it comes to killing ticks,\nveterinarians and pet owners want it done fast. New data published in\nParasites & Vectors\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1505575406&u=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1186%2Fs13071-026-07559-y&a=Parasites+%26+Vectors)\n, a leading peer-reviewed publication, demonstrates that Elanco Animal\nHealth's (NYSE: ELAN) Credelio Quattro™ (lotilaner, moxidectin,\npraziquantel, and pyrantel chewable tablets) kills ticks(1) faster(2) than\nleading competitors Simparica Trio(®) (sarolaner, moxidectin, and pyrantel\nchewable tablets) and NexGard(®) Plus (afoxolaner, moxidectin, and pyrantel\nchewable tablets).(i)\n\nNewly Published Data Found Credelio Quattro:\n\n * Faster(2) Tick(1) Speed of Kill: Credelio Quattro is the only product proven\nto significantly reduce black-legged ticks within 8 hours.(i ) Lotilaner, the\nactive ingredient in Credelio Quattro also has the fastest initial tick speed\nof kill against the lone star tick - in just 12 hours – and sustains the\nadvantage throughout the dosing interval.(ii)\n * Outperforms the Competition: Outperforms Simparica Trio(®) (12 hours) and\nNexGard(®) Plus (24 hours) at the end of the dosing period (Day 28).(i)\n * Consistency Over Competitors: Achieves 8-hour speed of kill(1) on Day 0 and\non Day 28 with no performance drop-off. Rapid kill is critical for preventing\nLyme disease transmission, which typically occurs 24-48 hours after\nattachment.(i)\n\"Speed of kill is a critical factor for veterinarians and pet owners when\nchoosing parasite coverage because the longer a tick is attached, the more\nlikely it is to transmit dangerous diseases, like Lyme disease, to pets,\" said\nDr. Casey Locklear\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2350501195&u=https%3A%2F%2Fwww.linkedin.com%2Fin%2Fcaseylockleardvm%2F&a=Dr.+Casey+Locklear)\n, veterinarian and leading parasiticides expert at Elanco. \"These results\nreinforce that lotilaner, the active ingredient in Credelio Quattro, not\nonly starts working fast but maintains its speed of kill(4) against multiple\nspecies of ticks(5), providing veterinarians and pet owners with the\nconfidence that their dogs are protected from the very start of the month to\nthe very end.\"\n\nThe black-legged tick is the primary vector for Borrelia burgdorferi, the\nbacterium responsible for Lyme disease and anaplasmosis. The study, which\nevaluated the speed of kill against Ixodes scapularis (black-legged tick),\nfound that Credelio Quattro was the only product tested to achieve\nsignificant initial tick reduction(2) within just 8 hours of infestation.\nNotably, this rapid speed of kill(1) was maintained from the beginning of the\nmonth through Day 28, providing consistent protection for the entire dosing\ninterval.(i)\n\n\"Ticks are on the move. They are no longer limited to the places or seasons\nwhere we have historically expected to find them,\" said Dr. Kathryn Reif,\nBailey-Goodwin Endowed Associate Professor in Parasitology at Auburn\nUniversity. \"As their geographic range expands, so does the risk of tick bites\nand exposure to the pathogens they carry. Because tick-borne diseases can\nthreaten the health of people, pets, and livestock, raising public awareness\nis more important than ever as tick populations grow and spread into new\nregions.\"\n\nThe findings are based on evaluation time points at 4, 8, 12, 24, and 48 hours\npost-treatment and reinfestation. The data demonstrates that Credelio\nQuattro outperforms Simparica Trio and NexGard Plus in rapid\ntick(1) reduction, particularly in the critical first 8 to 12 hours.(i)\n Speed of kill against Ixodes scapularis (black-legged tick)^ (i)\n Time point at which active achieved consistent superior efficacy vs.\n untreated control group(¥)\n Day of Study    Credelio Quattro                                      Simparica Trio                         NexGard Plus\n\n(lotilaner, moxidectin, praziquantel, and pyrantel)\n(sarolaner, moxidectin and pyrantel)\n(afoxolaner, moxidectin, and pyrantel)\n 0               8 hrs                                                 12 hrs                                 12 hrs\n 21              8 hrs                                                 24 hrs                                 24 hrs\n 28              8 hrs                                                 12 hrs                                 24 hrs\n ^Tick counts were evaluated at all 4-, 8-, 12-, 24-, and 48-hour time points\n as part of the study design\n\n(¥)P<0.05.\n\nCredelio Quattro also has a U.S. Food and Drug Administration approved\nclaim for prevention of Lyme disease in dogs as a direct result of killing\nblack-legged ticks.\n\nDoes Credelio Quattro Kill the Lone Star Tick?\n\nCredelio Quattro is approved to protect dogs from the lone star tick\n(Amblyomma americanum), and its active ingredient, lotilaner, also has the\nfastest(3) initial speed of tick kill against the lone star tick – in just\n12 hours – and sustains that advantage throughout the dosing interval.(ii)\nThis aggressive and expanding tick species – established across the South,\nMidwest and Northeast, and continuing to spread –  is one of the hardest to\nkill and is best known for its association with alpha-gal syndrome, or the red\nmeat allergy in humans. It can also transmit dangerous disease-causing\npathogens to dogs.(iii) A 2024 head-to-head study published in Parasites\n& Vectors\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=3203982664&u=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1186%2Fs13071-024-06363-w&a=head-to-head+study+published+in+Parasites+%26+Vectors)\n compared lotilaner, the active ingredient in Credelio (lotilaner) and\nCredelio Quattro with sarolaner in Simparica Trio and afoxolaner in\nNexGard(®), and found that lotilaner kills the lone star tick faster(4) than\nsarolaner in Simparica Trio and afoxolaner in NexGard, protecting dogs\nagainst this pathogen-carrying tick.\n Speed of kill against Amblyomma americanum (lone star tick)^ (ii)\n Time point at which active achieved consistent superior efficacy vs.\n untreated control group(¥)\n Day of Study  Credelio      Sarolaner                              NexGard\n\n(lotilaner)\n(sarolaner, moxidectin and pyrantel)\n(afoxolaner)\n 0             12 hrs        24 hrs                                 24 hrs\n 21            12 hrs        48 hrs                                 48 hrs\n 28            8 hrs         48 hrs                                 72 hrs\n ^Tick counts were evaluated at all 4-, 8-, 12-, 24-, 48-, and 72-hour time\n points as part of the study design\n\n(¥)P<0.05.\n\n\"With a heavier tick season and emergency room visits from tick bites on the\nrise(iv), pet owners should remain vigilant and keep their pets on year-round\nparasite coverage,\" Dr. Locklear notes. \"We continue to look for opportunities\nto make parasite protection stronger and evolve research around best-in-class\nmedicines.\"\n\nFrequently Asked Questions About Ticks and Credelio Quattro:\n\nHow fast does Credelio Quattro kill ticks?\n\nStudies show that lotilaner, the active ingredient in Credelio Quattro kills\nticks(5 ) faster(6) than the competition.(i,ii) A 2026 study published\nin Parasites & Vectors shows that Credelio Quattro achieved significant\nreduction(2) of black-legged ticks within 8 hours of infestation.(i) A 2024\nstudy shows that lotilaner, the active ingredient in Credelio and Credelio\nQuattro also has the fastest(3 )initial speed of tick kill against the lone\nstar tick – in just 12 hours – and sustains that advantage throughout the\ndosing interval.(ii)\n\nWhy is it important to kill ticks quickly?\n\nThe risk of disease transmission increases the longer a tick remains attached,\nmaking rapid speed of kill a critical factor in preventing the transmission of\ndisease. A 2026 study shows that Credelio Quattro was the only product tested\nthat significantly reduced(2) black-legged ticks within 8 hours.(i)\n\nDoes Credelio Quattro lose effectiveness to kill ticks(1) quickly at the end\nof the month?\n\nNo. The data shows that Credelio Quattro maintains its 8-hour speed of\nkill(2) on Day 28, whereas competitors showed a decline in performance.(i)\n\nAre black-legged ticks linked to the red meat allergy in humans?\n\nIn the United States, alpha-gal syndrome, or red meat allergy, is usually\nassociated with bites from the lone star tick (Amblyomma americanum); however,\ntwo Emerging Infectious Diseases studies\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2199504080&u=https%3A%2F%2Fwww.cidrap.umn.edu%2Ftick-borne-disease%2Fresearch-ties-bites-2-more-types-ticks-red-meat-allergy&a=Emerging+Infectious+Diseases%C2%A0studies)\nlink bites from black-legged ticks (deer ticks) and western black-legged ticks\nto potentially life-threatening alpha-gal syndrome.(v) Additional work will\nbe needed to determine a possible link, according to the researchers, but this\ncontinues to put emphasis on the need for tick bite protection for humans.\n\nTo learn more about Credelio Quattro visit CredelioQuattroVet.com.\n\nPM-US-26-1188\n\n 1. Ixodes scapularis (black-legged tick)\n 2. Based on the time to statistical significance vs. control in a head-to-head\nstudy on Day 0 post-treatment and Day 28 for reinfestations comparing\nCredelio Quattro, which contains lotilaner as well as moxidectin,\npraziquantel, and pyrantel—to the active ingredients in Simparica Trio\n(sarolaner, moxidectin, and pyrantel) and NexGard Plus (afoxolaner,\nmoxidectin, and pyrantel) against Ixodes scapularis.\n 3. Based on the time to statistical significance vs. control in a head-to-head\nstudy comparing Credelio (lotilaner)—not Credelio Quattro, which contains\nlotilaner as well as moxidectin, praziquantel, and pyrantel—to the active\ningredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and\nNexGard (afoxolaner).\n 4. Based on the time to statistical significance vs control in two separate\nhead-to-head studies. The first study compared Credelio (lotilaner)—not\nCredelio Quattro, which contains lotilaner as well as moxidectin,\npraziquantel, and pyrantel—to the active ingredients in Simparica Trio\n(sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner) against\nAmblyomma americanum. The second study compared Credelio Quattro, which\ncontains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the\nactive ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and\nNexGard Plus (afoxolaner, moxidectin, and pyrantel) against I. scapularis.\n 5. Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star\ntick)\nNexGard and NexGard Plus are registered trademarks of Boehringer Ingelheim\nAnimal Health USA Inc. Simparica Trio is a registered trademark of Zoetis\nServices LLC.\n\nCredelio Quattro, Credelio, Elanco and the diagonal bar logo are trademarks of\nElanco or its affiliates. Other company and product names are trademarks of\ntheir respective owners. © 2026 Elanco or its affiliates\n\nABOUT ELANCO\nElanco Animal Health Incorporated (NYSE: ELAN) is a global leader in animal\nhealth dedicated to innovating and delivering products and services to prevent\nand treat disease in farm animals and pets, creating value for farmers, pet\nowners, veterinarians, stakeholders and society as a whole. With 70 years of\nanimal health heritage, we are committed to breaking boundaries and going\nbeyond to help our customers improve the health of animals in their care,\nwhile also making a meaningful impact on our local and global communities. At\nElanco, we are driven by our vision of Food and Companionship Enriching Life\nand our purpose – all to Go Beyond for Animals, Customers, Society and Our\nPeople. Learn more at www.elanco.com (http://www.elanco.com) .\n\nIndications for Credelio Quattro/Credelio Quattro-CA1\n\nCredelio Quattro is indicated for the prevention of heartworm disease and the\ntreatment and control of roundworm, hookworm, and tapeworm infections.\nCredelio Quattro kills adult fleas and is indicated for the treatment and\nprevention of flea infestations and the treatment and control of tick\ninfestations for 1 month in dogs and puppies 8 weeks of age and older and\nweighing 3.3 pounds or greater. Credelio Quattro is indicated for the\nprevention of Lyme disease infections as a direct result of killing\nblack-legged ticks.\n\nCredelio Quattro-CA1 is conditionally approved for the treatment of\ninfestations caused by New World screwworm (NWS) larvae in dogs and puppies 8\nweeks of age and older and weighing 3.3 pounds or greater.\n\nImportant Safety Information for Credelio Quattro/Credelio Quattro-CA1\n\nLotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to\nthe isoxazoline class and has been associated with neurologic adverse\nreactions like tremors, incoordination, and seizures even in dogs without a\nhistory of seizures. Use with caution in dogs with a history of seizures or\nneurologic disorders. Dogs should be tested for existing heartworm infections\nbefore Credelio Quattro/Credelio Quattro-CA1 administration as it is not\neffective against adult heartworms. The safe use in breeding, pregnant, or\nlactating dogs has not been evaluated. The most frequently reported adverse\nreactions in clinical trials were vomiting and diarrhea.\n\nCredelio Quattro-CA1 is conditionally approved by the FDA pending a full\ndemonstration of effectiveness under application number 141-619. If you\nsuspect that your dog is infested with NWS larvae, seek veterinary care\nimmediately for treatment to include removal of larvae and appropriate wound\ncare.\n\nFor complete safety information, please see the Credelio Quattro/Credelio\nQuattro-CA1 product label\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=897575977&u=https%3A%2F%2Fedge.prnewswire.com%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4583688-1%26h%3D2039172994%26u%3Dhttps%253A%252F%252Fcredelioquattrolabel.com%252F%26a%3Dproduct%2Blabel&a=product+label)\n or ask your veterinarian.\n\nIndications for Credelio\nCredelio kills adult fleas and is indicated for the treatment and prevention\nof flea infestations and treatment and control of tick infestations (lone star\ntick, American dog tick, black-legged tick, brown dog tick, and longhorned\ntick) for one month in dogs and puppies 8 weeks and older and 4.4 pounds or\ngreater. Credelio is indicated for the prevention of Lyme disease infections\nas a direct result of killing black-legged ticks.\n\nImportant Safety Information for Credelio\nLotilaner is a member of the isoxazoline class of drugs. This class has been\nassociated with neurologic adverse reactions including tremors,\nincoordination, and seizures. Seizures have been reported in dogs receiving\nthis class of drugs, even in dogs without a history of seizures. Use with\ncaution in dogs with a history of seizures or neurologic disorders. The safe\nuse of Credelio in breeding, pregnant or lactating dogs has not been\nevaluated. The most frequently reported adverse reactions are weight loss,\nelevated blood urea nitrogen, increased urination, and diarrhea. For complete\nsafety information, please see Credelio product label\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1967243360&u=https%3A%2F%2Fwww.elancolabels.com%2Fus%2Fcredelio&a=product+label)\nor ask your veterinarian.\n\n(i) Reif, K.E., Kollasch, T.M., Locklear, C.L. et al. Comparative speed of\nkill of induced Ixodes scapularis infestations following treatment of dogs\nwith endectocides containing either sarolaner (Simparica Trio™), afoxolaner\n(NexGard(®) PLUS), or lotilaner (Credelio Quattro™). Parasites\nVectors (2026). https://doi.org/10.1186/s13071-026-07559-y\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1441809470&u=https%3A%2F%2Fdoi.org%2F10.1186%2Fs13071-026-07559-y&a=https%3A%2F%2Fdoi.org%2F10.1186%2Fs13071-026-07559-y)\n(\nii)  Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz\nMS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative\nspeed of kill provided by lotilaner (Credelio™), sarolaner (Simparica\nTrio™), and afoxolaner (NexGard™) to control Amblyomma\namericanum infestations on dogs. Parasite Vectors. 2024 Jul 20;17(1):313.\n(iii) Centers for Disease Control and Prevention. (n.d.). Where Ticks Live.\nCenters for Disease Control and Prevention. Retrieved August 8, 2024,\nfrom https://www.cdc.gov/ticks/about/where-ticks-live.html\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2481902105&u=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fabout%2Fwhere-ticks-live.html&a=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fabout%2Fwhere-ticks-live.html)\n\n(iv) CDC Data Show Weekly ER Visits for Tick Bites Higher Than Usual.\"\nCenters for Disease Control and Prevention, 23 Apr. 2026,\n(v) Van Beusekom, Mary. \"Research Ties Bites from 2 More Types of Ticks to\nRed Meat Allergy.\" CIDRAP (Center for Infectious Disease Research and Policy),\n4 Apr. 2025\n\nInvestor Contact: Tiffany Kanaga (765) 740-0314 tiffany.kanaga@elancoah.com\n(mailto:tiffany.kanaga@elancoah.com)\nMedia Contact: Season Solorio (765) 316-0233 season.solorio@elancoah.com\n(mailto:season.solorio@elancoah.com)\n\nView original content to download\nmultimedia:https://www.prnewswire.com/news-releases/credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-kills-ticks-faster-than-simparica-trio-sarolaner-moxidectin-and-pyrantel-chewable-tablets-and-nexgard-plus-afoxolaner-moxidectin-and-302831444.html\n(https://www.prnewswire.com/news-releases/credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-kills-ticks-faster-than-simparica-trio-sarolaner-moxidectin-and-pyrantel-chewable-tablets-and-nexgard-plus-afoxolaner-moxidectin-and-302831444.html)\n\nSOURCE Elanco Animal Health\n\n\n\nPhoto: \nhttps://mmx.prnewswire.com/media/MS653209/Elanco-Logo.jpg?id=OA2777905\n\nCopyright (c) 2026 PR Newswire Association,LLC. All Rights Reserved.","article_body_html":"","raw_payload":{"data":{"id":"nPn7KxgzGa","title":"Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)","author":"PR Newswire","ticker":"ELAN","created":"2026-07-22T10:27:00.017Z","tickers":["ELAN"],"exchange":"NYSE","article_body":"Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)\n\nPR Newswire\n\nINDIANAPOLIS, July 22, 2026\n\nPublished Data Shows that the Active Ingredient, Lotilaner, in Credelio\nQuattro:\n\n * Kills existing black-legged tick (Ixodes scapularis) infestations faster(2)\nthan leading competitors, within just 8 hours of treatment.(i)\n * Kills the lone star tick (Amblyomma americanum) within 12 hours of\ninfestation; achieving the fastest(3) initial speed of tick kill compared to\nthe competition.(ii)\n * Achieves a rapid speed of kill(4) on Day 0 and on Day 28, with no\nstatistically significant drop-off in performance at the end of the dosing\nperiod.(i,ii)\n * Outlasts competitors whose speed of kill(2,4) performance declined at the end\nof the month.(i,ii)\nINDIANAPOLIS, July 22, 2026 /PRNewswire/ -- When it comes to killing ticks,\nveterinarians and pet owners want it done fast. New data published in\nParasites & Vectors\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1505575406&u=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1186%2Fs13071-026-07559-y&a=Parasites+%26+Vectors)\n, a leading peer-reviewed publication, demonstrates that Elanco Animal\nHealth's (NYSE: ELAN) Credelio Quattro™ (lotilaner, moxidectin,\npraziquantel, and pyrantel chewable tablets) kills ticks(1) faster(2) than\nleading competitors Simparica Trio(®) (sarolaner, moxidectin, and pyrantel\nchewable tablets) and NexGard(®) Plus (afoxolaner, moxidectin, and pyrantel\nchewable tablets).(i)\n\nNewly Published Data Found Credelio Quattro:\n\n * Faster(2) Tick(1) Speed of Kill: Credelio Quattro is the only product proven\nto significantly reduce black-legged ticks within 8 hours.(i ) Lotilaner, the\nactive ingredient in Credelio Quattro also has the fastest initial tick speed\nof kill against the lone star tick - in just 12 hours – and sustains the\nadvantage throughout the dosing interval.(ii)\n * Outperforms the Competition: Outperforms Simparica Trio(®) (12 hours) and\nNexGard(®) Plus (24 hours) at the end of the dosing period (Day 28).(i)\n * Consistency Over Competitors: Achieves 8-hour speed of kill(1) on Day 0 and\non Day 28 with no performance drop-off. Rapid kill is critical for preventing\nLyme disease transmission, which typically occurs 24-48 hours after\nattachment.(i)\n\"Speed of kill is a critical factor for veterinarians and pet owners when\nchoosing parasite coverage because the longer a tick is attached, the more\nlikely it is to transmit dangerous diseases, like Lyme disease, to pets,\" said\nDr. Casey Locklear\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2350501195&u=https%3A%2F%2Fwww.linkedin.com%2Fin%2Fcaseylockleardvm%2F&a=Dr.+Casey+Locklear)\n, veterinarian and leading parasiticides expert at Elanco. \"These results\nreinforce that lotilaner, the active ingredient in Credelio Quattro, not\nonly starts working fast but maintains its speed of kill(4) against multiple\nspecies of ticks(5), providing veterinarians and pet owners with the\nconfidence that their dogs are protected from the very start of the month to\nthe very end.\"\n\nThe black-legged tick is the primary vector for Borrelia burgdorferi, the\nbacterium responsible for Lyme disease and anaplasmosis. The study, which\nevaluated the speed of kill against Ixodes scapularis (black-legged tick),\nfound that Credelio Quattro was the only product tested to achieve\nsignificant initial tick reduction(2) within just 8 hours of infestation.\nNotably, this rapid speed of kill(1) was maintained from the beginning of the\nmonth through Day 28, providing consistent protection for the entire dosing\ninterval.(i)\n\n\"Ticks are on the move. They are no longer limited to the places or seasons\nwhere we have historically expected to find them,\" said Dr. Kathryn Reif,\nBailey-Goodwin Endowed Associate Professor in Parasitology at Auburn\nUniversity. \"As their geographic range expands, so does the risk of tick bites\nand exposure to the pathogens they carry. Because tick-borne diseases can\nthreaten the health of people, pets, and livestock, raising public awareness\nis more important than ever as tick populations grow and spread into new\nregions.\"\n\nThe findings are based on evaluation time points at 4, 8, 12, 24, and 48 hours\npost-treatment and reinfestation. The data demonstrates that Credelio\nQuattro outperforms Simparica Trio and NexGard Plus in rapid\ntick(1) reduction, particularly in the critical first 8 to 12 hours.(i)\n Speed of kill against Ixodes scapularis (black-legged tick)^ (i)\n Time point at which active achieved consistent superior efficacy vs.\n untreated control group(¥)\n Day of Study    Credelio Quattro                                      Simparica Trio                         NexGard Plus\n\n(lotilaner, moxidectin, praziquantel, and pyrantel)\n(sarolaner, moxidectin and pyrantel)\n(afoxolaner, moxidectin, and pyrantel)\n 0               8 hrs                                                 12 hrs                                 12 hrs\n 21              8 hrs                                                 24 hrs                                 24 hrs\n 28              8 hrs                                                 12 hrs                                 24 hrs\n ^Tick counts were evaluated at all 4-, 8-, 12-, 24-, and 48-hour time points\n as part of the study design\n\n(¥)P<0.05.\n\nCredelio Quattro also has a U.S. Food and Drug Administration approved\nclaim for prevention of Lyme disease in dogs as a direct result of killing\nblack-legged ticks.\n\nDoes Credelio Quattro Kill the Lone Star Tick?\n\nCredelio Quattro is approved to protect dogs from the lone star tick\n(Amblyomma americanum), and its active ingredient, lotilaner, also has the\nfastest(3) initial speed of tick kill against the lone star tick – in just\n12 hours – and sustains that advantage throughout the dosing interval.(ii)\nThis aggressive and expanding tick species – established across the South,\nMidwest and Northeast, and continuing to spread –  is one of the hardest to\nkill and is best known for its association with alpha-gal syndrome, or the red\nmeat allergy in humans. It can also transmit dangerous disease-causing\npathogens to dogs.(iii) A 2024 head-to-head study published in Parasites\n& Vectors\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=3203982664&u=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1186%2Fs13071-024-06363-w&a=head-to-head+study+published+in+Parasites+%26+Vectors)\n compared lotilaner, the active ingredient in Credelio (lotilaner) and\nCredelio Quattro with sarolaner in Simparica Trio and afoxolaner in\nNexGard(®), and found that lotilaner kills the lone star tick faster(4) than\nsarolaner in Simparica Trio and afoxolaner in NexGard, protecting dogs\nagainst this pathogen-carrying tick.\n Speed of kill against Amblyomma americanum (lone star tick)^ (ii)\n Time point at which active achieved consistent superior efficacy vs.\n untreated control group(¥)\n Day of Study  Credelio      Sarolaner                              NexGard\n\n(lotilaner)\n(sarolaner, moxidectin and pyrantel)\n(afoxolaner)\n 0             12 hrs        24 hrs                                 24 hrs\n 21            12 hrs        48 hrs                                 48 hrs\n 28            8 hrs         48 hrs                                 72 hrs\n ^Tick counts were evaluated at all 4-, 8-, 12-, 24-, 48-, and 72-hour time\n points as part of the study design\n\n(¥)P<0.05.\n\n\"With a heavier tick season and emergency room visits from tick bites on the\nrise(iv), pet owners should remain vigilant and keep their pets on year-round\nparasite coverage,\" Dr. Locklear notes. \"We continue to look for opportunities\nto make parasite protection stronger and evolve research around best-in-class\nmedicines.\"\n\nFrequently Asked Questions About Ticks and Credelio Quattro:\n\nHow fast does Credelio Quattro kill ticks?\n\nStudies show that lotilaner, the active ingredient in Credelio Quattro kills\nticks(5 ) faster(6) than the competition.(i,ii) A 2026 study published\nin Parasites & Vectors shows that Credelio Quattro achieved significant\nreduction(2) of black-legged ticks within 8 hours of infestation.(i) A 2024\nstudy shows that lotilaner, the active ingredient in Credelio and Credelio\nQuattro also has the fastest(3 )initial speed of tick kill against the lone\nstar tick – in just 12 hours – and sustains that advantage throughout the\ndosing interval.(ii)\n\nWhy is it important to kill ticks quickly?\n\nThe risk of disease transmission increases the longer a tick remains attached,\nmaking rapid speed of kill a critical factor in preventing the transmission of\ndisease. A 2026 study shows that Credelio Quattro was the only product tested\nthat significantly reduced(2) black-legged ticks within 8 hours.(i)\n\nDoes Credelio Quattro lose effectiveness to kill ticks(1) quickly at the end\nof the month?\n\nNo. The data shows that Credelio Quattro maintains its 8-hour speed of\nkill(2) on Day 28, whereas competitors showed a decline in performance.(i)\n\nAre black-legged ticks linked to the red meat allergy in humans?\n\nIn the United States, alpha-gal syndrome, or red meat allergy, is usually\nassociated with bites from the lone star tick (Amblyomma americanum); however,\ntwo Emerging Infectious Diseases studies\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2199504080&u=https%3A%2F%2Fwww.cidrap.umn.edu%2Ftick-borne-disease%2Fresearch-ties-bites-2-more-types-ticks-red-meat-allergy&a=Emerging+Infectious+Diseases%C2%A0studies)\nlink bites from black-legged ticks (deer ticks) and western black-legged ticks\nto potentially life-threatening alpha-gal syndrome.(v) Additional work will\nbe needed to determine a possible link, according to the researchers, but this\ncontinues to put emphasis on the need for tick bite protection for humans.\n\nTo learn more about Credelio Quattro visit CredelioQuattroVet.com.\n\nPM-US-26-1188\n\n 1. Ixodes scapularis (black-legged tick)\n 2. Based on the time to statistical significance vs. control in a head-to-head\nstudy on Day 0 post-treatment and Day 28 for reinfestations comparing\nCredelio Quattro, which contains lotilaner as well as moxidectin,\npraziquantel, and pyrantel—to the active ingredients in Simparica Trio\n(sarolaner, moxidectin, and pyrantel) and NexGard Plus (afoxolaner,\nmoxidectin, and pyrantel) against Ixodes scapularis.\n 3. Based on the time to statistical significance vs. control in a head-to-head\nstudy comparing Credelio (lotilaner)—not Credelio Quattro, which contains\nlotilaner as well as moxidectin, praziquantel, and pyrantel—to the active\ningredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and\nNexGard (afoxolaner).\n 4. Based on the time to statistical significance vs control in two separate\nhead-to-head studies. The first study compared Credelio (lotilaner)—not\nCredelio Quattro, which contains lotilaner as well as moxidectin,\npraziquantel, and pyrantel—to the active ingredients in Simparica Trio\n(sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner) against\nAmblyomma americanum. The second study compared Credelio Quattro, which\ncontains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the\nactive ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and\nNexGard Plus (afoxolaner, moxidectin, and pyrantel) against I. scapularis.\n 5. Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star\ntick)\nNexGard and NexGard Plus are registered trademarks of Boehringer Ingelheim\nAnimal Health USA Inc. Simparica Trio is a registered trademark of Zoetis\nServices LLC.\n\nCredelio Quattro, Credelio, Elanco and the diagonal bar logo are trademarks of\nElanco or its affiliates. Other company and product names are trademarks of\ntheir respective owners. © 2026 Elanco or its affiliates\n\nABOUT ELANCO\nElanco Animal Health Incorporated (NYSE: ELAN) is a global leader in animal\nhealth dedicated to innovating and delivering products and services to prevent\nand treat disease in farm animals and pets, creating value for farmers, pet\nowners, veterinarians, stakeholders and society as a whole. With 70 years of\nanimal health heritage, we are committed to breaking boundaries and going\nbeyond to help our customers improve the health of animals in their care,\nwhile also making a meaningful impact on our local and global communities. At\nElanco, we are driven by our vision of Food and Companionship Enriching Life\nand our purpose – all to Go Beyond for Animals, Customers, Society and Our\nPeople. Learn more at www.elanco.com (http://www.elanco.com) .\n\nIndications for Credelio Quattro/Credelio Quattro-CA1\n\nCredelio Quattro is indicated for the prevention of heartworm disease and the\ntreatment and control of roundworm, hookworm, and tapeworm infections.\nCredelio Quattro kills adult fleas and is indicated for the treatment and\nprevention of flea infestations and the treatment and control of tick\ninfestations for 1 month in dogs and puppies 8 weeks of age and older and\nweighing 3.3 pounds or greater. Credelio Quattro is indicated for the\nprevention of Lyme disease infections as a direct result of killing\nblack-legged ticks.\n\nCredelio Quattro-CA1 is conditionally approved for the treatment of\ninfestations caused by New World screwworm (NWS) larvae in dogs and puppies 8\nweeks of age and older and weighing 3.3 pounds or greater.\n\nImportant Safety Information for Credelio Quattro/Credelio Quattro-CA1\n\nLotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to\nthe isoxazoline class and has been associated with neurologic adverse\nreactions like tremors, incoordination, and seizures even in dogs without a\nhistory of seizures. Use with caution in dogs with a history of seizures or\nneurologic disorders. Dogs should be tested for existing heartworm infections\nbefore Credelio Quattro/Credelio Quattro-CA1 administration as it is not\neffective against adult heartworms. The safe use in breeding, pregnant, or\nlactating dogs has not been evaluated. The most frequently reported adverse\nreactions in clinical trials were vomiting and diarrhea.\n\nCredelio Quattro-CA1 is conditionally approved by the FDA pending a full\ndemonstration of effectiveness under application number 141-619. If you\nsuspect that your dog is infested with NWS larvae, seek veterinary care\nimmediately for treatment to include removal of larvae and appropriate wound\ncare.\n\nFor complete safety information, please see the Credelio Quattro/Credelio\nQuattro-CA1 product label\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=897575977&u=https%3A%2F%2Fedge.prnewswire.com%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4583688-1%26h%3D2039172994%26u%3Dhttps%253A%252F%252Fcredelioquattrolabel.com%252F%26a%3Dproduct%2Blabel&a=product+label)\n or ask your veterinarian.\n\nIndications for Credelio\nCredelio kills adult fleas and is indicated for the treatment and prevention\nof flea infestations and treatment and control of tick infestations (lone star\ntick, American dog tick, black-legged tick, brown dog tick, and longhorned\ntick) for one month in dogs and puppies 8 weeks and older and 4.4 pounds or\ngreater. Credelio is indicated for the prevention of Lyme disease infections\nas a direct result of killing black-legged ticks.\n\nImportant Safety Information for Credelio\nLotilaner is a member of the isoxazoline class of drugs. This class has been\nassociated with neurologic adverse reactions including tremors,\nincoordination, and seizures. Seizures have been reported in dogs receiving\nthis class of drugs, even in dogs without a history of seizures. Use with\ncaution in dogs with a history of seizures or neurologic disorders. The safe\nuse of Credelio in breeding, pregnant or lactating dogs has not been\nevaluated. The most frequently reported adverse reactions are weight loss,\nelevated blood urea nitrogen, increased urination, and diarrhea. For complete\nsafety information, please see Credelio product label\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1967243360&u=https%3A%2F%2Fwww.elancolabels.com%2Fus%2Fcredelio&a=product+label)\nor ask your veterinarian.\n\n(i) Reif, K.E., Kollasch, T.M., Locklear, C.L. et al. Comparative speed of\nkill of induced Ixodes scapularis infestations following treatment of dogs\nwith endectocides containing either sarolaner (Simparica Trio™), afoxolaner\n(NexGard(®) PLUS), or lotilaner (Credelio Quattro™). Parasites\nVectors (2026). https://doi.org/10.1186/s13071-026-07559-y\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=1441809470&u=https%3A%2F%2Fdoi.org%2F10.1186%2Fs13071-026-07559-y&a=https%3A%2F%2Fdoi.org%2F10.1186%2Fs13071-026-07559-y)\n(\nii)  Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz\nMS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative\nspeed of kill provided by lotilaner (Credelio™), sarolaner (Simparica\nTrio™), and afoxolaner (NexGard™) to control Amblyomma\namericanum infestations on dogs. Parasite Vectors. 2024 Jul 20;17(1):313.\n(iii) Centers for Disease Control and Prevention. (n.d.). Where Ticks Live.\nCenters for Disease Control and Prevention. Retrieved August 8, 2024,\nfrom https://www.cdc.gov/ticks/about/where-ticks-live.html\n(https://edge.prnewswire.com/c/link/?t=0&l=en&o=4736216-1&h=2481902105&u=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fabout%2Fwhere-ticks-live.html&a=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fabout%2Fwhere-ticks-live.html)\n\n(iv) CDC Data Show Weekly ER Visits for Tick Bites Higher Than Usual.\"\nCenters for Disease Control and Prevention, 23 Apr. 2026,\n(v) Van Beusekom, Mary. \"Research Ties Bites from 2 More Types of Ticks to\nRed Meat Allergy.\" CIDRAP (Center for Infectious Disease Research and Policy),\n4 Apr. 2025\n\nInvestor Contact: Tiffany Kanaga (765) 740-0314 tiffany.kanaga@elancoah.com\n(mailto:tiffany.kanaga@elancoah.com)\nMedia Contact: Season Solorio (765) 316-0233 season.solorio@elancoah.com\n(mailto:season.solorio@elancoah.com)\n\nView original content to download\nmultimedia:https://www.prnewswire.com/news-releases/credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-kills-ticks-faster-than-simparica-trio-sarolaner-moxidectin-and-pyrantel-chewable-tablets-and-nexgard-plus-afoxolaner-moxidectin-and-302831444.html\n(https://www.prnewswire.com/news-releases/credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-kills-ticks-faster-than-simparica-trio-sarolaner-moxidectin-and-pyrantel-chewable-tablets-and-nexgard-plus-afoxolaner-moxidectin-and-302831444.html)\n\nSOURCE Elanco Animal Health\n\n\n\nPhoto: \nhttps://mmx.prnewswire.com/media/MS653209/Elanco-Logo.jpg?id=OA2777905\n\nCopyright (c) 2026 PR Newswire Association,LLC. All Rights Reserved."},"type":"article","timestamp":"2026-07-22T10:27:00.089566756Z","server_sent_at_ms":1784716020089},"received_at":"2026-07-22T10:27:00.242Z","source_url":"https://www.prnewswire.com/news-releases/credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-kills-ticks-faster-than-simparica-trio-sarolaner-moxidectin-and-pyrantel-chewable-tablets-and-nexgard-plus-afoxolaner-moxidectin-and-302831444.html"},"analysis":{"id":"83910","press_release_id":"94865","analysis_json":{"industry":{"label":"Pharmaceuticals","sector":"Health Care"},"redFlags":[],"eventType":"operations_update","narrative":"New data published in Parasites & Vectors demonstrates that Elanco's Credelio Quattro kills ticks faster than leading competitors Simparica Trio and NexGard Plus.\n\nThe study found Credelio Quattro significantly reduced black-legged tick infestations within 8 hours and lone star ticks within 12 hours, with no performance drop-off at the end of the 28-day dosing period.\n\nThis rapid speed of kill supports the product's FDA-approved claim for preventing Lyme disease by killing the primary vector, the black-legged tick, before disease transmission typically occurs.","sentiment":"bullish","agentHooks":{"shouldPost":false,"suggestedAngle":"Head-to-head study shows Elanco's Credelio Quattro kills ticks faster than Zoetis and Boehringer rival products."},"keyFigures":{"drugName":"Credelio Quattro","customDimensions":{"lone_star_tick_kill_time":"12 hours","black_legged_tick_kill_time":"8 hours","dosing_period_effectiveness":"Day 28"}},"quotedText":"Speed of kill is a critical factor for veterinarians and pet owners when choosing parasite coverage because the longer a tick is attached, the more likely it is to transmit dangerous diseases, like Lyme disease, to pets","namedEntities":{"people":[{"name":"Dr. Casey Locklear","role":"Veterinarian and parasiticides expert at Elanco"},{"name":"Dr. Kathryn Reif","role":"Bailey-Goodwin Endowed Associate Professor in Parasitology at Auburn University"},{"name":"Tiffany Kanaga","role":"Investor Contact"},{"name":"Season Solorio","role":"Media Contact"}],"products":["Credelio Quattro","Simparica Trio","NexGard Plus","Credelio","NexGard"],"companies":[{"name":"Elanco Animal Health","ticker":"ELAN"},{"name":"Zoetis Services LLC","relationship":"competitor"},{"name":"Boehringer Ingelheim Animal Health USA Inc.","relationship":"competitor"},{"name":"Auburn University","relationship":"research_partner"}],"dollarAmounts":[]},"materialImpact":{"score":3,"reasoning":"Newly published peer-reviewed data demonstrates competitive superiority of Credelio Quattro against major rivals Simparica Trio and NexGard Plus. While not a binary regulatory event, this differentiation supports commercial momentum and market share defense in the parasiticide market."},"tickerRelevance":{"others":[],"primary":"ELAN"},"globalImportance":20,"audienceRelevance":15,"eventTypeSecondary":[],"importanceComponents":{"tickerTier":"mid-cap","eventGravity":"comparative_product_data","sectorWeight":"animal_health"}},"event_type":"operations_update","event_type_secondary":null,"sentiment":"bullish","material_impact_score":3,"narrative":"New data published in Parasites & Vectors demonstrates that Elanco's Credelio Quattro kills ticks faster than leading competitors Simparica Trio and NexGard Plus.\n\nThe study found Credelio Quattro significantly reduced black-legged tick infestations within 8 hours and lone star ticks within 12 hours, with no performance drop-off at the end of the 28-day dosing period.\n\nThis rapid speed of kill supports the product's FDA-approved claim for preventing Lyme disease by killing the primary vector, the black-legged tick, before disease transmission typically occurs.","key_figures":{"drugName":"Credelio Quattro","customDimensions":{"lone_star_tick_kill_time":"12 hours","black_legged_tick_kill_time":"8 hours","dosing_period_effectiveness":"Day 28"}},"named_entities":{"people":[{"name":"Dr. Casey Locklear","role":"Veterinarian and parasiticides expert at Elanco"},{"name":"Dr. Kathryn Reif","role":"Bailey-Goodwin Endowed Associate Professor in Parasitology at Auburn University"},{"name":"Tiffany Kanaga","role":"Investor Contact"},{"name":"Season Solorio","role":"Media Contact"}],"products":["Credelio Quattro","Simparica Trio","NexGard Plus","Credelio","NexGard"],"companies":[{"name":"Elanco Animal Health","ticker":"ELAN"},{"name":"Zoetis Services LLC","relationship":"competitor"},{"name":"Boehringer Ingelheim Animal Health USA Inc.","relationship":"competitor"},{"name":"Auburn University","relationship":"research_partner"}],"dollarAmounts":[]},"model_name":"glm-4.7","prompt_hash":"sha256:727b4b9429a443af","schema_hash":"sha256:05005c02d9cffac9","created_at":"2026-07-22T10:48:25.469Z","global_importance":20,"audience_relevance":15,"importance_components":{"tickerTier":"mid-cap","eventGravity":"comparative_product_data","sectorWeight":"animal_health"}},"durationMs":334745,"modelName":"glm-4.7"}}